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| http://purl.uniprot.org/citations/9657150 | http://www.w3.org/2000/01/rdf-schema#comment | "We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which accompanies a defect in neuronal differentiation. Reduction in the Drosophila beta-catenin, Armadillo (Arm), rescues the differentiation defect and prevents apoptosis in the D-APC mutant, while Arm overexpression mimics D-APC inactivation. A mutation in dTCF, the DNA-binding protein required in Arm-mediated signal transduction, can eliminate the cell death without rescuing the differentiation defect in D-APC mutants. Uncoupling of these two Arm-induced processes suggests a novel role for the Arm/dTCF complex in the activation of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81461-0"xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/author | "Hayashi S."xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/author | "Levine A."xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/author | "Ahmed Y."xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/author | "Wieschaus E."xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/pages | "1171-1182"xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/title | "Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development."xsd:string |
| http://purl.uniprot.org/citations/9657150 | http://purl.uniprot.org/core/volume | "93"xsd:string |
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