http://purl.uniprot.org/citations/9660748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9660748 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/9660748 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras. Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1). A juxtamembrane segment of FGFR-1 and the phosphotyrosine-binding domain of SNTs are both necessary and sufficient for interaction in yeast and in vitro, and FGFR-mediated SNT tyrosine phosphorylation in vivo requires these segments of receptor and SNT. Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways. The SNT binding motif of FGFR-1 is distinct from previously described phosphotyrosine-binding domain recognition motifs, lacking both tyrosine and asparagine residues."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.29.17987"xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.29.17987"xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/author | "Lee K.W."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/author | "Lee K.W."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/author | "Goldfarb M.P."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/author | "Goldfarb M.P."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/pages | "17987-17990"xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/pages | "17987-17990"xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/title | "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/title | "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins."xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/volume | "273"xsd:string |
http://purl.uniprot.org/citations/9660748 | http://purl.uniprot.org/core/volume | "273"xsd:string |
http://purl.uniprot.org/citations/9660748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9660748 |
http://purl.uniprot.org/citations/9660748 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9660748 |
http://purl.uniprot.org/citations/9660748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9660748 |
http://purl.uniprot.org/citations/9660748 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9660748 |