| http://purl.uniprot.org/citations/9670003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9670003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9670003 | http://www.w3.org/2000/01/rdf-schema#comment | "We have used differential display to identify genes whose expression is altered in type 2 diabetes thus contributing to its pathogenesis. One mRNA is overexpressed in fibroblasts from type 2 diabetics compared with non-diabetic individuals, as well as in skeletal muscle and adipose tissues, two major sites of insulin resistance in type 2 diabetes. The levels of the protein encoded by this mRNA are also elevated in type 2 diabetic tissues; thus, we named it PED for phosphoprotein enriched in diabetes. PED cloning shows that it encodes a 15 kDa phosphoprotein identical to the protein kinase C (PKC) substrate PEA-15. The PED gene maps on human chromosome 1q21-22. Transfection of PED/PEA-15 in differentiating L6 skeletal muscle cells increases the content of Glut1 transporters on the plasma membrane and inhibits insulin-stimulated glucose transport and cell-surface recruitment of Glut4, the major insulin-sensitive glucose transporter. These effects of PED overexpression are reversed by blocking PKC activity. Overexpression of the PED/PEA-15 gene may contribute to insulin resistance in glucose uptake in type 2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.14.3858"xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.14.3858"xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Tecce M.F."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Tecce M.F."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Condorelli G."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Condorelli G."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Caruso M."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Caruso M."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Beguinot F."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Beguinot F."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Cafieri A."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Cafieri A."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Formisano P."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Formisano P."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Vigliotta G."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Vigliotta G."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Iavarone C."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Iavarone C."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Andreozzi F."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Andreozzi F."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Beguinot L."xsd:string |
| http://purl.uniprot.org/citations/9670003 | http://purl.uniprot.org/core/author | "Beguinot L."xsd:string |