| http://purl.uniprot.org/citations/9671304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9671304 | http://www.w3.org/2000/01/rdf-schema#comment | "In neural systems, information is often carried by ensembles of cells rather than by individual units. Optical indicators provide a powerful means to reveal such distributed activity, particularly when protein-based and encodable in DNA: encodable probes can be introduced into cells, tissues, or transgenic organisms by genetic manipulation, selectively expressed in anatomically or functionally defined groups of cells, and, ideally, recorded in situ, without a requirement for exogenous cofactors. Here we describe sensors for secretion and neurotransmission that fulfil these criteria. We have developed pH-sensitive mutants of green fluorescent protein ('pHluorins') by structure-directed combinatorial mutagenesis, with the aim of exploiting the acidic pH inside secretory vesicles to monitor vesicle exocytosis and recycling. When linked to a vesicle membrane protein, pHluorins were sorted to secretory and synaptic vesicles and reported transmission at individual synaptic boutons, as well as secretion and fusion pore 'flicker' of single secretory granules."xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.org/dc/terms/identifier | "doi:10.1038/28190"xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/author | "Rothman J.E."xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/author | "De Angelis D.A."xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/author | "Miesenbock G."xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/pages | "192-195"xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/title | "Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins."xsd:string |
| http://purl.uniprot.org/citations/9671304 | http://purl.uniprot.org/core/volume | "394"xsd:string |
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| http://purl.uniprot.org/uniprot/#_E9Q6P9-mappedCitation-9671304 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671304 |
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