| http://purl.uniprot.org/citations/9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9671459 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogen-induced progression through G1 phase of the cell cycle is preceded by increased expression of the G1-phase regulatory proteins c-Myc and cyclin D1. To investigate the potential contribution of these proteins to estrogen action, we derived clonal MCF-7 breast cancer cell lines in which c-Myc or cyclin D1 was expressed under the control of the metal-inducible metallothionein promoter. Inducible expression of either c-Myc or cyclin D1 was sufficient for S-phase entry in cells previously arrested in G1 phase by pretreatment with ICI 182780, a potent estrogen antagonist. c-Myc expression was not accompanied by increased cyclin D1 expression or Cdk4 activation, nor was cyclin D1 induction accompanied by increases in c-Myc. Expression of c-Myc or cyclin D1 was sufficient to activate cyclin E-Cdk2 by promoting the formation of high-molecular-weight complexes lacking the cyclin-dependent kinase inhibitor p21, as has been described, following estrogen treatment. Interestingly, this was accompanied by an association between active cyclin E-Cdk2 complexes and hyperphosphorylated p130, identifying a previously undefined role for p130 in estrogen action. These data provide evidence for distinct c-Myc and cyclin D1 pathways in estrogen-induced mitogenesis which converge on or prior to the formation of active cyclin E-Cdk2-p130 complexes and loss of inactive cyclin E-Cdk2-p21 complexes, indicating a physiologically relevant role for the cyclin E binding motifs shared by p130 and p21."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.18.8.4499"xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/author | "Sutherland R.L."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/author | "Watts C.K."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/author | "Musgrove E.A."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/author | "Prall O.W."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/author | "Rogan E.M."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/pages | "4499-4508"xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/title | "c-Myc or cyclin D1 mimics estrogen effects on cyclin E-Cdk2 activation and cell cycle reentry."xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/9671459 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9671459 |
| http://purl.uniprot.org/citations/9671459 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9671459 |
| http://purl.uniprot.org/uniprot/#_P0C5Y9-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P57053-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P58876-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P03372-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P62805-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P62807-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_Q14683-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P33778-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P53539-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |
| http://purl.uniprot.org/uniprot/#_P84243-mappedCitation-9671459 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9671459 |