| http://purl.uniprot.org/citations/9671816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9671816 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9671816 | http://www.w3.org/2000/01/rdf-schema#comment | "Interphase chromatin is arranged into topologically separated domains comprising gene expression and replication units through genomic sequence elements, so-called MAR or SAR regions (for matrix- or scaffold-associating regions). S/MAR regions are located near the boundaries of actively transcribed genes and were shown to influence their activity. We show that scaffold attachment factor B (SAF-B), which specifically binds to S/MAR regions, interacts with RNA polymerase II (RNA pol II) and a subset of serine-/arginine-rich RNA processing factors (SR proteins). SAF-B localized to the nucleus in a speckled pattern that coincided with the distribution of the SR protein SC35. Furthermore, we show that overexpressed SAF-B induced an increase of the 10S splice product using an E1A reporter gene and repressed the activity of an S/MAR flanked CAT reporter gene construct in vivo . This indicates an association of SAF-B with SR proteins and components of the transcription machinery. Our results describe the coupling of a chromatin organizing S/MAR element with transcription and pre-mRNA processing components and we propose that SAF-B serves as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/26.15.3542"xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/26.15.3542"xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Stamm S."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Stamm S."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Stagljar I."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Stagljar I."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Hartmann A.M."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Hartmann A.M."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Nayler O."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Nayler O."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Jasper H."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Jasper H."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Bourquin J.-P."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Bourquin J.-P."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Fackelmeyer F.O."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Fackelmeyer F.O."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Lindemann L."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Lindemann L."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Straetling W."xsd:string |
| http://purl.uniprot.org/citations/9671816 | http://purl.uniprot.org/core/author | "Straetling W."xsd:string |