| http://purl.uniprot.org/citations/9677190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9677190 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9677190 | http://www.w3.org/2000/01/rdf-schema#comment | "Selective protein kinase inhibitors were developed on the basis of the unexpected binding mode of 2,6,9-trisubstituted purines to the adenosine triphosphate-binding site of the human cyclin-dependent kinase 2 (CDK2). By iterating chemical library synthesis and biological screening, potent inhibitors of the human CDK2-cyclin A kinase complex and of Saccharomyces cerevisiae Cdc28p were identified. The structural basis for the binding affinity and selectivity was determined by analysis of a three-dimensional crystal structure of a CDK2-inhibitor complex. The cellular effects of these compounds were characterized in mammalian cells and yeast. In the latter case the effects were characterized on a genome-wide scale by monitoring changes in messenger RNA levels in treated cells with high-density oligonucleotide probe arrays. Purine libraries could provide useful tools for analyzing a variety of signaling and regulatory pathways and may lead to the development of new therapeutics."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.281.5376.533"xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.281.5376.533"xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Barnes G."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Barnes G."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Schultz P.G."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Schultz P.G."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Meijer L."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Meijer L."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Morgan D.O."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Leclerc S."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Leclerc S."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Kwon S."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Kwon S."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Gray N.S."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Gray N.S."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Lockhart D.J."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Lockhart D.J."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Wodicka L."xsd:string |
| http://purl.uniprot.org/citations/9677190 | http://purl.uniprot.org/core/author | "Wodicka L."xsd:string |