| http://purl.uniprot.org/citations/9677419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9677419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9677419 | http://www.w3.org/2000/01/rdf-schema#comment | "The thiol amino acid homocysteine (HC) accumulates in homocystinuria and homocyst(e)inemia, and is associated with a wide variety of clinical manifestations. To determine whether HC influences the cell's program of gene expression, vascular endothelial cells were treated with HC for 6-42 h and analyzed by differential display. We found a 3-7-fold, time-dependent induction of a 220-base pair fragment, which demonstrated complete sequence identity with elongation factor-1delta (EF-1delta), a member of the multimeric complex regulating mRNA translation. Fibroblasts from cystathionine beta-synthase -/-individuals also showed up to 3.0-fold increased levels of mRNA for EF-1alpha, -beta, and -delta when compared with normal cells, and treatment of normal cells with the HC precursor, methionine, induced a 1.5-2.0-fold increase in EF-1alpha, -beta, and -delta mRNA. This induction was completely inhibited by cycloheximide and reflected a doubling in the rate of gene transcription in nuclear run-on analyses. In HC-treated endothelial cells, pulse-chase studies revealed a doubling in the rate of synthesis of the thiol-containing protein, annexin II, but no change in synthesis of the cysteineless protein, plasminogen activator inhibitor-1. Thus, HC induces expression of a family of acute translational response genes through a protein synthesis-dependent transcriptional mechanism. This process may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.31.19840"xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.31.19840"xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/author | "Ling Q."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/author | "Ling Q."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/author | "Hajjar K.A."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/author | "Hajjar K.A."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/author | "Chacko G."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/author | "Chacko G."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/pages | "19840-19846"xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/pages | "19840-19846"xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/title | "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/title | "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta."xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9677419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9677419 |
| http://purl.uniprot.org/citations/9677419 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9677419 |
| http://purl.uniprot.org/citations/9677419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9677419 |
| http://purl.uniprot.org/citations/9677419 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9677419 |