| http://purl.uniprot.org/citations/9681435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9681435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9681435 | http://www.w3.org/2000/01/rdf-schema#comment | "We report the isolation of a full-length eel tyrosine hydroxylase (TH) cDNA that is characterized by a long 3' untranslated region and by a diversity restricted to the 3' end owing to the differential use of three polyadenylation signals. The longest eel TH mRNA was distinctive in the presence of four pentameric elements (AUUUA) in the AU-rich 3' noncoding region. Such a diversity could provide the basis of posttranscriptional or translational regulation of eel TH gene expression. Comparison of the eel TH sequence with those of other aromatic amino acid hydroxylases (TH, tryptophan hydroxylase, and phenylalanine hydroxylase) and phylogenetic analysis confirmed that the N-terminal regulatory domain is highly divergent, contrasting with the conservation of the catalytic core of the enzyme. Molecular phylogenies including the available sequences of the three hydroxylase genes suggested that the duplication of their common ancestor occurred before the emergence of arthropods. The regional expression of the eel TH mRNA was studied by semiquantitative PCR, northern blots, and in situ hybridization and compared with the immunocytochemical localization of TH protein. The data showed that TH mRNA is mostly expressed in the olfactory and hypothalamic areas, whereas sparse TH-expressing cell bodies are present in the telencephalic region and brainstem. No labeling was detected in the mesencephalic area, in striking contrast with that found in amphibians and amniotes."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.1998.71020460.x"xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1471-4159.1998.71020460.x"xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Mallet J."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Mallet J."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Veron M."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Veron M."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Vernier P."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Vernier P."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Boularand S."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Boularand S."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Biguet N.F."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Biguet N.F."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Vidal B."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Vidal B."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Dufour S."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Dufour S."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Vincent J.D."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/author | "Vincent J.D."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |
| http://purl.uniprot.org/citations/9681435 | http://purl.uniprot.org/core/name | "J. Neurochem."xsd:string |