| http://purl.uniprot.org/citations/9681517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9681517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9681517 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclooxygenase (COX) is the first rate-limiting enzyme in the biosynthesis of PGs. There are two isoforms, COX-1, a constitutive enzyme and COX-2, the induced form, products of two different genes. In this study, we report COX-2 complementary DNA cloning, uterine expression, and immunohistochemical localization in the mink uterus during postimplantation gestation. The open reading frame of mink COX-2 contains 1812 nucleotides encoding 604 amino acids. The homologies are 86%, 83%, 83%, 83%, 85%, and 84% in nucleotides and 86%, 87%, 87%, 85%, 86%, and 88% in amino acids with human, mouse, rat, guinea pig, sheep, and rabbit, respectively. All domains associated with biological activity are conserved in the mink. Northern analysis revealed a transcript of 4.2 kb for COX-2 in mink uterus and adrenal. Semiquantitative RT-PCR showed that COX-2 messenger RNA is not present during diapause. The abundance of COX-2 messenger RNA reached its maxima (P < 0.05) on days 3-5 of postimplantation, gradually decreased through day 9, and was not present thereafter. By immunohistochemistry, COX-2 was present in uterine epithelium, stroma, and necks of endometrial glands at sites of implantation. COX-2 expression appears to be induced in the endometrium by the embryo and may play a role in implantation and placentation in the mink."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.139.8.6142"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.139.8.6142"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Sirois J."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Sirois J."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Houde A."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Houde A."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Song J.H."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Song J.H."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Murphy B.D."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/author | "Murphy B.D."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/pages | "3629-3636"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/pages | "3629-3636"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/title | "Cloning, developmental expression, and immunohistochemistry of cyclooxygenase 2 in the endometrium during embryo implantation and gestation in the mink (Mustela vison)."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/title | "Cloning, developmental expression, and immunohistochemistry of cyclooxygenase 2 in the endometrium during embryo implantation and gestation in the mink (Mustela vison)."xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/9681517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9681517 |
| http://purl.uniprot.org/citations/9681517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9681517 |