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| http://purl.uniprot.org/citations/9687002 | http://www.w3.org/2000/01/rdf-schema#comment | "Methadone, a potent opioid analgesic, has long been considered a mu-opioid, based upon the similarities between its actions and those of morphine. This classification is supported by the sensitivity of methadone analgesia to the highly mu-opioid receptor-selective antagonist beta-funaltrexamine. Yet, CXBK mice respond normally to methadone despite their insensitivity to systemic morphine, distinguishing between the receptor mechanisms of the two drugs. Beta-funaltrexamine antagonizes methadone analgesia in CXBK mice, implying that the opioid is still acting through a mu-opioid receptor. These results reveal distinct analgesic mechanisms for morphine and methadone and provide further support for multiple subtypes of mu-opioid receptors."xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-2999(98)00366-5"xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/author | "Chang A."xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/author | "Pasternak G.W."xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/author | "Rossi G.C."xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/author | "Emmel D.W."xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/name | "Eur J Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/pages | "189-191"xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/title | "Methadone analgesia in morphine-insensitive CXBK mice."xsd:string |
| http://purl.uniprot.org/citations/9687002 | http://purl.uniprot.org/core/volume | "351"xsd:string |
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