| http://purl.uniprot.org/citations/9687499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9687499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9687499 | http://www.w3.org/2000/01/rdf-schema#comment | "Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrate that at least two active alleles of these genes are required for extrauterine life. Mice carrying only one intact allele [G alpha q(-/+);G alpha 11(-/-) or G alpha q(-/-);G alpha 11(-/+)] died shortly after birth. These mutants showed a high incidence of cardiac malformation. In addition, G alpha q(-/-);G alpha 11(-/+) newborns suffered from craniofacial defects. Mice lacking both G alpha q and G alpha 11 [G alpha q(-/-);G alpha 11(-/-)] died at embryonic day 11 due to cardiomyocyte hypoplasia. These data demonstrate overlap in G alpha q and G alpha 11 gene functions and indicate that the Gq class of G proteins plays a crucial role in cardiac growth and development."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.15.4304"xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.15.4304"xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Simon M.I."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Simon M.I."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Wilkie T.M."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Wilkie T.M."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Offermanns S."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Offermanns S."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Sarosi I."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Sarosi I."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Gohla A."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Gohla A."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Zhao L.P."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/author | "Zhao L.P."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/pages | "4304-4312"xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/pages | "4304-4312"xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/title | "Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice."xsd:string |
| http://purl.uniprot.org/citations/9687499 | http://purl.uniprot.org/core/title | "Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice."xsd:string |