| http://purl.uniprot.org/citations/9687510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9687510 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9687510 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a novel mitogen- and stress-activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to UV radiation, and oxidative and chemical stress. The activation of MSK1 by growth factors/phorbol esters is prevented by PD 98059, which suppresses activation of the MAPK cascade, while the activation of MSK1 by stress stimuli is prevented by SB 203580, a specific inhibitor of SAPK2/p38. In HeLa, PC12 and SK-N-MC cells, PD 98059 and SB 203580 are both required to suppress the activation of MSK1 by TNF, NGF and FGF, respectively, because these agonists activate both the MAPK/ERK and SAPK2/p38 cascades. MSK1 is localized in the nucleus of unstimulated or stimulated cells, and phosphorylates CREB at Ser133 with a Km value far lower than PKA, MAPKAP-K1(p90Rsk) and MAPKAP-K2. The effects of SB 203580, PD 98059 and Ro 318220 on agonist-induced activation of CREB and ATF1 in four cell-lines mirror the effects of these inhibitors on MSK1 activation, and exclude a role for MAPKAP-K1 and MAPKAP-K2/3 in this process. These findings, together with other observations, suggest that MSK1 may mediate the growth-factor and stress-induced activation of CREB."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.15.4426"xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/17.15.4426"xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Alessi D.R."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Alessi D.R."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Deak M."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Deak M."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Lucocq J.M."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Lucocq J.M."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Clifton A.D."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/author | "Clifton A.D."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/pages | "4426-4441"xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/pages | "4426-4441"xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/title | "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/title | "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/9687510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9687510 |
| http://purl.uniprot.org/citations/9687510 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9687510 |