| http://purl.uniprot.org/citations/9693135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9693135 | http://www.w3.org/2000/01/rdf-schema#comment | "Kidney glomerulus mesangial cells fail to develop in mice carrying targeted null mutations in the platelet-derived growth factor (PDGF)-B or PDGF-Rbeta genes. We have examined the pattern of expression of these genes and smooth muscle markers during kidney development, to address the possible mechanisms underlying the mutant phenotypes. In wild-type embryos, PDGF-B was expressed in vascular endothelial cells, particularly in capillary endothelial cells in the developing glomeruli, whereas PDGF-Rbeta was found in perivascular mesenchymal cells in the developing renal cortex. In the course of glomerular development, small groups of PDGF-Rbeta and desmin-expressing cells collected in the 'S'-shaped and early cup-shaped vesicles, and at later stages such cells were found in the glomerular mesangium. In PDGF-B or -Rbeta null embryos, some PDGF-Rbeta/desmin or desmin-positive cells, respectively, were seen in early cup-shaped vesicles, but fewer than in the wild type, and further development of the mesangium failed. In mouse chimeras composed of PDGF-Rbeta +/+ and -/- cells, the Rbeta-/-cells failed to populate the glomerular mesangium. Our results show that while the mesangial cell lineage is specified independently of PDGF-B/Rbeta, these molecules provide critical permissive signals in mesangial cell development. We propose a model in which mesangial cells originate from PDGF-Rbeta-positive progenitors surrounding the developing glomerular afferent and efferent arterioles, and are co-recruited in response to PDGF-B during angiogenic formation of the glomerular capillary tuft."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.125.17.3313"xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Betsholtz C."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Lindahl P."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Pekny M."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Karlsson L."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Pekna M."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Soriano P."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Hellstrom M."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/author | "Kalen M."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/pages | "3313-3322"xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/title | "Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli."xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/9693135 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9693135 |
| http://purl.uniprot.org/citations/9693135 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9693135 |
| http://purl.uniprot.org/uniprot/P31240#attribution-3B4B7474BF5232B99AA3A3652212630B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9693135 |
| http://purl.uniprot.org/uniprot/P31240#attribution-BE55F8DAF889BB0B5B454993CF57828C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9693135 |
| http://purl.uniprot.org/uniprot/P05622#attribution-3B4B7474BF5232B99AA3A3652212630B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9693135 |
| http://purl.uniprot.org/uniprot/P05622#attribution-BE55F8DAF889BB0B5B454993CF57828C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9693135 |
| http://purl.uniprot.org/uniprot/#_A0A0R4IZW4-mappedCitation-9693135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9693135 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHJ1-mappedCitation-9693135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9693135 |
| http://purl.uniprot.org/uniprot/#_A0A2R8W6F2-mappedCitation-9693135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9693135 |