| http://purl.uniprot.org/citations/9696811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9696811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9696811 | http://www.w3.org/2000/01/rdf-schema#comment | "We used the yeast interaction trap system to identify a novel human 70-kDa protein, termed NS1-binding protein (NS1-BP), which interacts with the nonstructural NS1 protein of the influenza A virus. The genetic interaction was confirmed by the specific coprecipitation of the NS1 protein from solution by a glutathione S-transferase-NS1-BP fusion protein and glutathione-Sepharose. NS1-BP contains an N-terminal BTB/POZ domain and five kelch-like tandem repeat elements of approximately 50 amino acids. In noninfected cells, affinity-purified antibodies localized NS1-BP in nuclear regions enriched with the spliceosome assembly factor SC35, suggesting an association of NS1-BP with the cellular splicing apparatus. In influenza A virus-infected cells, NS1-BP relocalized throughout the nucleoplasm and appeared distinct from the SC35 domains, which suggests that NS1-BP function may be disturbed or altered. The addition of a truncated NS1-BP mutant protein to a HeLa cell nuclear extract efficiently inhibited pre-mRNA splicing but not spliceosome assembly. This result could be explained by a possible dominant-negative effect of the NS1-BP mutant protein and suggests a role of the wild-type NS1-BP in promoting pre-mRNA splicing. These data suggest that the inhibition of splicing by the NS1 protein may be mediated by binding to NS1-BP."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.72.9.7170-7180.1998"xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.72.9.7170-7180.1998"xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/author | "Palese P."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/author | "Palese P."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/author | "Wolff T."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/author | "Wolff T."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/author | "O'Neill R.E."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/author | "O'Neill R.E."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/pages | "7170-7180"xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/pages | "7170-7180"xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/title | "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/title | "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells."xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/9696811 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9696811 |
| http://purl.uniprot.org/citations/9696811 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9696811 |
| http://purl.uniprot.org/citations/9696811 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9696811 |
| http://purl.uniprot.org/citations/9696811 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9696811 |