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| http://purl.uniprot.org/citations/9697730 | http://www.w3.org/2000/01/rdf-schema#comment | "Germ-free C57BL/6 x 129 interferon-gamma knockout (IFN-gamma(-/-)) mice and their immunocompetent (+/-, +/+) counterparts were colonized with a pure culture of Candida albicans to assess their natural susceptibility to mucosal and systemic candidiasis of endogenous origin. Colonization with a pure culture of C. albicans was not lethal for adult or neonatal IFN-gamma(-/-) gnotobiotic mice over the 15-week study. The IFN-gamma(-/-) mice were more susceptible to gastric (cardia-antrum section), anorectal, and acute systemic (intravenous challenge) candidiasis than immunocompetent controls, and some IFN-gamma(-/-) mice developed intestinal adenomas after colonization with C. albicans. The enhanced susceptibility of IFN-gamma(-/-) mice, compared with immunocompetent controls, may be associated with a poor proliferative response of spleen cells to C. albicans antigens and a T helper 2 (IgG1) serum antibody response to C. albicans antigens. Thus, IFN-gamma is important for murine resistance to gastric, anorectal, and acute systemic candidiasis."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.org/dc/terms/identifier | "doi:10.1086/515645"xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/author | "Warner T."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/author | "Balish E."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/author | "Pierson C."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/author | "Vazquez-Torres A."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/author | "Wagner R.D."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/pages | "478-487"xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/title | "Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice."xsd:string |
| http://purl.uniprot.org/citations/9697730 | http://purl.uniprot.org/core/volume | "178"xsd:string |
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