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http://purl.uniprot.org/citations/9697832http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9697832http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9697832http://www.w3.org/2000/01/rdf-schema#comment"The human IL-4 receptor contains a sequence (the 14R motif) centered on Y497 that, when phosphorylated, interacts with phosphotyrosine-binding (PTB) domain proteins. Here, we describe a PTB domain protein, FRIP, that is phosphorylated in response to cytokine stimulation. FRIP is related to the rasGAP-associated protein p62dok and is bound by the N-terminal SH2 domain of rasGAP. The frip gene maps to the hairless (hr) locus on mouse chromosome 14. hr/hr mice exhibit lymphadenopathy, and their lymph node T cells proliferate more vigorously to anti-CD3 with IL-4 or IL-2 stimulation than +/hr T cells. FRIP expression is significantly reduced in T cells from hr/hr mice. FRIP may negatively regulate proliferation by acting as an adapter molecule between rasGAP and receptor complexes."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80584-1"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.org/dc/terms/identifier"doi:10.1016/s1074-7613(00)80584-1"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Paul W.E."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Paul W.E."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Snow A.L."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Snow A.L."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Hu-Li J."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Hu-Li J."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Nelms K."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/author"Nelms K."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/pages"13-24"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/pages"13-24"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/title"FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/title"FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation."xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/9697832http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/9697832http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9697832
http://purl.uniprot.org/citations/9697832http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9697832