| http://purl.uniprot.org/citations/9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9701566 | http://www.w3.org/2000/01/rdf-schema#comment | "The docking/fusion of transport vesicles mediated by the soluble NSF attachment protein receptors (SNAREs) is thought to be regulated by Sec1-related proteins. Munc-18-2, a member of this family, is predominantly expressed in the epithelial cells of several tissues. We demonstrate here that Munc-18-2 colocalizes with syntaxin 3 at the apical plasma membrane of intestinal epithelium and Caco-2 cells. The presence of a physical complex of the two proteins is verified by 2-way coimmunoprecipitation. The quantity of the complex is reduced by treatment of Caco-2 cells with the alkylating agent N-ethylmaleimide which also has an inhibitory effect on the ability of Munc-18-2 to associate with syntaxin 3 in vitro. The amount of Munc-18-2 in the complex increases upon treatment of the cells with the protein kinase C activator phorbol myristate acetate, indicating a functional connection between the complex and cell signalling. Increasing the amount of Munc-18-2 bound to syntaxin 3 by overexpression results in a marked decrease in the SNARE proteins SNAP-23 and cellubrevin bound to the syntaxin. These results define a novel functional complex of Munc-18-2 and syntaxin 3 involved in the regulation of apical membrane transport."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.111.17.2681"xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/author | "Jansson S."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/author | "Ehnholm C."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/author | "Olkkonen V.M."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/author | "Galli T."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/author | "Lehtonen E."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/author | "Riento K."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/pages | "2681-2688"xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/title | "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/9701566 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9701566 |
| http://purl.uniprot.org/citations/9701566 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9701566 |
| http://purl.uniprot.org/uniprot/#_P61764-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_P63027-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_A0A140LHM1-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRC2-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_A0A1C7CYU4-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_A0A140LIF1-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ60-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_A0A140LJH9-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |
| http://purl.uniprot.org/uniprot/#_O14795-mappedCitation-9701566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9701566 |