| http://purl.uniprot.org/citations/9702742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9702742 | http://www.w3.org/2000/01/rdf-schema#comment | "Anatomical, pharmacological and human post-mortem studies suggest the dopamine D3 receptor (DRD3) gene as a candidate for drug dependence. We thus performed an association study of the Bal I polymorphism at the DRD3 gene, including 54 opiate addicts and 70 controls. Opiate addicts had a higher sensation-seeking score (on the Zückerman scale) than controls (P = 0.001), particularly a subgroup (70%) who had a distinctly higher score, exceeding 24. There were no marked differences in genotypes between patients as a whole and controls. However, patients with a sensation-seeking score above 24 were more frequently homozygotes for both alleles than patients with a sensation-seeking score under 24 (P = 0.038) or controls (P = 0.034). Although obtained in a sample of limited size, these results suggest that the DRD3 gene may have a role in drug dependence susceptibility in individuals with high sensation-seeking scores. This hypothesis is consistent with the role of DRD3 in mediating responses to drugs of abuse in animals and the association of homozygosity at the Bal I polymorphism with drug abuse in schizophrenic patients (see companion article by Krebs et al)."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.mp.4000409"xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Schwartz J.C."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Ades J."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Gorwood P."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Griffon N."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Sokoloff P."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Bourdel M.C."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Duaux E."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Loo H."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Poirier M.F."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/author | "Sautel F."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/name | "Mol Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/pages | "333-336"xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/title | "Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence."xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/9702742 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9702742 |
| http://purl.uniprot.org/citations/9702742 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9702742 |
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| http://purl.uniprot.org/uniprot/#_A8K8E4-mappedCitation-9702742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9702742 |
| http://purl.uniprot.org/uniprot/#_Q13167-mappedCitation-9702742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9702742 |
| http://purl.uniprot.org/uniprot/#_P35462-mappedCitation-9702742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9702742 |