| http://purl.uniprot.org/citations/9703499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9703499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9703499 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-alpha (TNF-alpha) is a major mediator of both acute and chronic inflammatory responses in many diseases. Tristetraprolin (TTP), the prototype of a class of Cys-Cys-Cys-His (CCCH) zinc finger proteins, inhibited TNF-alpha production from macrophages by destabilizing its messenger RNA. This effect appeared to result from direct TTP binding to the AU-rich element of the TNF-alpha messenger RNA. TTP is a cytosolic protein in these cells, and its biosynthesis was induced by the same agents that stimulate TNF-alpha production, including TNF-alpha itself. These findings identify TTP as a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its messenger RNA. This pathway represents a potential target for anti-TNF-alpha therapies."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.281.5379.1001"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.281.5379.1001"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/author | "Blackshear P.J."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/author | "Blackshear P.J."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/author | "Lai W.S."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/author | "Lai W.S."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/author | "Carballo E."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/author | "Carballo E."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/pages | "1001-1005"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/pages | "1001-1005"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/title | "Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/title | "Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin."xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/9703499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9703499 |
| http://purl.uniprot.org/citations/9703499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9703499 |
| http://purl.uniprot.org/citations/9703499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9703499 |
| http://purl.uniprot.org/citations/9703499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9703499 |