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http://purl.uniprot.org/citations/9705271http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9705271http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9705271http://www.w3.org/2000/01/rdf-schema#comment"Genetic studies in yeast have indicated a role of the RAD50 and MRE11 genes in homologous recombination, telomere length maintenance, and DNA repair processes. Here, we purify from nuclear extract of Raji cells a complex consisting of human Rad50, Mre11, and another protein factor with a size of about 95 kDa (p95), which is likely to be Nibrin, the protein encoded by the gene mutated in Nijmegen breakage syndrome. We show that the Rad50-Mre11-p95 complex possesses manganese-dependent single-stranded DNA endonuclease and 3' to 5' exonuclease activities. These nuclease activities are likely to be important for recombination, repair, and genomic stability."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.org/dc/terms/identifier"doi:10.1074/jbc.273.34.21447"xsd:string
http://purl.uniprot.org/citations/9705271http://purl.org/dc/terms/identifier"doi:10.1074/jbc.273.34.21447"xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Sung P."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Sung P."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Lee E.Y.-H.P."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Lee E.Y.-H.P."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Trujillo K.M."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Trujillo K.M."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Yuan S.-S.F."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/author"Yuan S.-S.F."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/pages"21447-21450"xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/pages"21447-21450"xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/title"Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/title"Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95."xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/volume"273"xsd:string
http://purl.uniprot.org/citations/9705271http://purl.uniprot.org/core/volume"273"xsd:string
http://purl.uniprot.org/citations/9705271http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9705271
http://purl.uniprot.org/citations/9705271http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9705271