| http://purl.uniprot.org/citations/9705938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9705938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9705938 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the tumor necrosis factor receptor (TNFR) superfamily have an important role in the induction of cellular signals resulting in cell growth, differentiation and death. TNFR-1 recruits and assembles a signaling complex containing a number of death domain (DD)-containing proteins, including the adaptor protein TRADD and the serine/threonine kinase RIP, which mediates TNF-induced NF-kappa B activation. RIP also recruits caspase-2 to the TNFR-1 signaling complex via the adaptor protein RAIDD, which contains a DD and a caspase-recruiting domain (CARD). Here, we have identified a RIP-like kinase, termed CARDIAK (for CARD-containing interleukin (IL)-1 beta converting enzyme (ICE) associated kinase), which contains a serine/threonine kinase domain and a carboxy-terminal CARD. Overexpression of CARDIAK induced the activation of both NF-kappa B and Jun N-terminal kinase (JNK). CARDIAK interacted with the TNFR-associated factors TRAF-1 and TRAF-2, and a dominant-negative form of TRAF-2 inhibited CARDIAK-induced NF-kappa B activation. Interestingly, CARDIAK specifically interacted with the CARD of caspase-1 (previously known as ICE), and this interaction correlated with the processing of pro-caspase-1 and the formation of the active p20 subunit of caspase-1. Together, these data suggest that CARDIAK may be involved in NF-kappa B/JNK signaling and in the generation of the proinflammatory cytokine IL-1 beta through activation of caspase-1."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(07)00352-1"xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(07)00352-1"xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Bodmer J.-L."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Bodmer J.-L."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Mattmann C."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Mattmann C."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Thome M."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Thome M."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Martinon F."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/author | "Martinon F."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/pages | "885-888"xsd:string |
| http://purl.uniprot.org/citations/9705938 | http://purl.uniprot.org/core/pages | "885-888"xsd:string |