| http://purl.uniprot.org/citations/9707631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9707631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9707631 | http://www.w3.org/2000/01/rdf-schema#comment | "Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons. Here, we describe the cloning and characterization of an ASIC splice variant, ASIC-beta, which contains a unique N-terminal 172 aa, as well as unique 5' and 3' untranslated sequences. ASIC-beta, unlike ASIC and DRASIC, is found only in a subset of small and large diameter sensory neurons and is absent from sympathetic neurons or the central nervous system. The patterns of expression of ASIC and ASIC-beta transcripts in rat dorsal root ganglion neurons are distinct. When expressed in COS-7 cells, ASIC-beta forms a functional channel with electrophysiological properties distinct from ASIC and DRASIC. The pH dependency and sensitivity to amiloride of ASIC-beta is similar to that described for ASIC, but unlike ASIC, the channel is not permeable to calcium, nor are ASIC-beta-mediated currents inhibited by extracellular calcium. The unique distribution of ASIC-beta suggests that it may play a specialized role in sensory neuron function."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.17.10240"xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.17.10240"xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "Wood J.N."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "Wood J.N."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "Chen C.-C."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "Chen C.-C."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "Akopian A.N."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "Akopian A.N."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "England S."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/author | "England S."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/pages | "10240-10245"xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/pages | "10240-10245"xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/title | "A sensory neuron-specific, proton-gated ion channel."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/title | "A sensory neuron-specific, proton-gated ion channel."xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9707631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9707631 |
| http://purl.uniprot.org/citations/9707631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9707631 |