| http://purl.uniprot.org/citations/9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9708735 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a critical upstream activator of caspases through gene targeting in mice. The majority of Casp9 knockout mice die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development. Casp9 deletion prevents activation of Casp3 in embryonic brains in vivo, and Casp9-deficient thymocytes show resistance to a subset of apoptotic stimuli, including absence of Casp3-like cleavage and delayed DNA fragmentation. Moreover, the cytochrome c-mediated cleavage of Casp3 is absent in the cytosolic extracts of Casp9-deficient cells but is restored after addition of in vitro-translated Casp9. Together, these results indicate that Casp9 is a critical upstream activator of the caspase cascade in vivo."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81476-2"xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Rakic P."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Karasuyama H."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Kuida K."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Su M.S."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Taya C."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Haydar T.F."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/author | "Kuan C.Y."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/pages | "325-337"xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/title | "Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9."xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/9708735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9708735 |
| http://purl.uniprot.org/citations/9708735 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9708735 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9708735 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRX1-mappedCitation-9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9708735 |
| http://purl.uniprot.org/uniprot/#_A2AS92-mappedCitation-9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9708735 |
| http://purl.uniprot.org/uniprot/#_A2AS93-mappedCitation-9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9708735 |
| http://purl.uniprot.org/uniprot/#_G3XA09-mappedCitation-9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9708735 |
| http://purl.uniprot.org/uniprot/#_Q8BNT4-mappedCitation-9708735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9708735 |