| http://purl.uniprot.org/citations/9722567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9722567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9722567 | http://www.w3.org/2000/01/rdf-schema#comment | "Forkhead-related activator 2 (FREAC-2) is a human transcription factor expressed in lung and placenta that binds to cis-elements in several lung-specific genes. We have identified the parts of FREAC-2 responsible for trans-activation and found two functionally redundant activation domains on the C-terminal side of the DNA binding forkhead domain. Activation domain 1 consists of the most C-terminal 23 amino acids of FREAC-2 and contains a sequence motif conserved in an activation domain of another forkhead protein, FREAC-1. Activation domain 2 is built up by three synergistic subdomains in the central part of the FREAC-2 protein. FREAC-2 was shown to interact in vitro with TBP and TFIIB. The target site for FREAC-2 on TBP was localized to the N-terminal repeat in the core domain of TBP. TFIIB binds FREAC-2 close to the cleft between its two globular domains. The part of FREAC-2 that binds TBP was mapped to 21 amino acids in the C-terminal end of the forkhead domain. This sequence is well conserved among forkhead proteins, raising the possibility that interaction with TBP may be a general characteristic of this family of transcription factors. Overexpression of TFIIB potentiates activation by FREAC-2 in a manner dependent on the FREAC-2 activation domains. Nuclear localization of FREAC-2 was found to depend on sequences from both ends of the forkhead domain."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.36.23335"xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.36.23335"xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Carlsson P."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Carlsson P."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Enerbaeck S."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Enerbaeck S."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Blixt A."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Blixt A."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Hellqvist M."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Hellqvist M."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Mahlapuu M."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/author | "Mahlapuu M."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/pages | "23335-23343"xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/pages | "23335-23343"xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/title | "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/title | "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB."xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9722567 | http://purl.uniprot.org/core/volume | "273"xsd:string |