| http://purl.uniprot.org/citations/9723620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9723620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9723620 | http://www.w3.org/2000/01/rdf-schema#comment | "During endocytosis, clathrin and the clathrin adaptor protein AP-2, assisted by a variety of accessory factors, help to generate an invaginated bud at the cell membrane. One of these factors is Eps15, a clathrin-coat-associated protein that binds the alpha-adaptin subunit of AP-2. Here we investigate the function of Eps15 by characterizing an important binding partner for its region containing EH domains; this protein, epsin, is closely related to the Xenopus mitotic phosphoprotein MP90 and has a ubiquitous tissue distribution. It is concentrated together with Eps15 in presynaptic nerve terminals, which are sites specialized for the clathrin-mediated endocytosis of synaptic vesicles. The central region of epsin binds AP-2 and its carboxy-terminal region binds Eps15. Epsin is associated with clathrin coats in situ, can be co-precipitated with AP-2 and Eps15 from brain extracts, but does not co-purify with clathrin coat components in a clathrin-coated vesicle fraction. When epsin function is disrupted, clathrin-mediated endocytosis is blocked. We propose that epsin may participate, together with Eps15, in the molecular rearrangement of the clathrin coats that are required for coated-pit invagination and vesicle fission."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.org/dc/terms/identifier | "doi:10.1038/29555"xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.org/dc/terms/identifier | "doi:10.1038/29555"xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Di Fiore P.P."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Di Fiore P.P."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "De Camilli P."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "De Camilli P."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Butler M.H."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Butler M.H."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Slepnev V.I."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Slepnev V.I."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Fre S."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Fre S."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Capua M.R."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/author | "Capua M.R."xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/9723620 | http://purl.uniprot.org/core/name | "Nature"xsd:string |