| http://purl.uniprot.org/citations/9724795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9724795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9724795 | http://www.w3.org/2000/01/rdf-schema#comment | "The t(8;21) translocation between two genes known as AML1 and ETO is seen in approximately 12-15% of all acute myeloid leukemia (AML) and is the second-most-frequently observed nonrandom genetic alteration associated with AML. AML1 up-regulates a number of target genes critical to normal hematopoiesis, whereas the AML1/ETO fusion interferes with this trans-activation. We discovered that the fusion partner ETO binds to the human homolog of the murine nuclear receptor corepressor (N-CoR). The interaction is mediated by two unusual zinc finger motifs present at the carboxyl terminus of ETO. Human N-CoR (HuN-CoR), which we cloned and sequenced in its entirety, encodes a 2,440-amino acid polypeptide and has a central domain that binds ETO. N-CoR, mammalian Sin3 (mSin3A and B), and histone deacetylase 1 (HDAC1) form a complex that alters chromatin structure and mediates transcriptional repression by nuclear receptors and by a number of oncoregulatory proteins. We found that ETO, through its interaction with the N-CoR/mSin3/HDAC1 complex, is also a potent repressor of transcription. This observation provides a mechanism for how the AML1/ETO fusion may inhibit expression of AML1-responsive target genes and disturb normal hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.18.10860"xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.18.10860"xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Hoshino T."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Hoshino T."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Kajigaya S."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Kajigaya S."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Liu J.M."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Liu J.M."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Redner R.L."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/author | "Redner R.L."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/pages | "10860-10865"xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/pages | "10860-10865"xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/title | "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/title | "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex."xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9724795 | http://purl.uniprot.org/core/volume | "95"xsd:string |