| http://purl.uniprot.org/citations/9725213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9725213 | http://www.w3.org/2000/01/rdf-schema#comment | "CD45 is a transmembrane protein tyrosine phosphatase essential for Ag receptor-mediated signaling in both T and B cells. In this study we investigated roles of CD45 in development and cytolytic activities of murine intestinal intraepithelial lymphocytes (i-IEL) using CD45 exon 6 knockout (CD45-/-) mice. Interestingly, the total cell number of i-IEL was significantly reduced in CD45-/-mice during aging (10-20 wk of age), whereas the i-IEL number was normally increased in the wild-type littermates. Especially, the number of gamma(delta)TCR+ i-IEL decreased markedly in CD45-/-mice during aging. The i-IEL in CD45-/-mice were more susceptible to in vitro spontaneous apoptosis than the normal i-IEL, implying that CD45 is required for maintenance of the cellularity of i-IEL. Results from in vivo analyses of the extrathymic and intrathymic development of i-IEL suggested that CD45-mediated signaling is required for the intrathymic, but not the extrathymic, development of i-IEL. Moreover, the whole i-IEL from CD45-/-mice showed a significantly reduced cytolytic activity, and the residual cytolytic activity was completely diminished by depleting CD45+ i-IEL, suggesting that CD45 is indispensable for the TCR-mediated cytolytic activity of i-IEL. Furthermore, we found differential contributions of CD45 and p56lck to development and induction of cytolytic activities of i-IEL."xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/author | "Nomoto K."xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/author | "Kong Y.Y."xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/author | "Yada S."xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/pages | "2208-2216"xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/title | "Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/9725213 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9725213 |
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