| http://purl.uniprot.org/citations/9727007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9727007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9727007 | http://www.w3.org/2000/01/rdf-schema#comment | "The mesangial cell provides structural support to the kidney glomerulus. A polymerase chain reaction-based cDNA display approach identified a novel protein-tyrosine phosphatase, rPTP-GMC1, whose transcript expression is transiently and dramatically up-regulated during the period of mesangial cell migration and proliferation that follows mesangial cell injury in the anti-Thy 1 model of mesangial proliferative glomerulonephritis in the rat. In situ hybridization analysis confirmed that rPTP-GMC1 mRNA is up-regulated specifically by mesangial cells responding to the injury and is not detectable in other cells in the kidney or in many normal tissues. In cell culture, rPTP-GMC1 is expressed by mesangial cells but not by glomerular endothelial or epithelial cells (podocytes). The longest transcript (7.5 kilobases) encodes a receptor-like protein-tyrosine phosphatase consisting of a single catalytic domain, a transmembrane segment, and 18 fibronectin type III-like repeats in the extracellular segment. A splice variant predicts a truncated molecule missing the catalytic domain. rPTP-GMC1 maps to human chromosome 12q15 and to the distal end of mouse chromosome 10. The predicted structure of rPTP-GMC1 and its pattern of expression in vivo and in culture suggest that it plays a role in regulating the adhesion and migration of mesangial cells in response to injury."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.37.23929"xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.37.23929"xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Disteche C.M."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Disteche C.M."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Seifert R."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Seifert R."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Wright M.B."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Wright M.B."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Bowen-Pope D.F."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Bowen-Pope D.F."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Hugo C."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/author | "Hugo C."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/pages | "23929-23937"xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/pages | "23929-23937"xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/title | "Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/title | "Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis."xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9727007 | http://purl.uniprot.org/core/volume | "273"xsd:string |