| http://purl.uniprot.org/citations/9727977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9727977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9727977 | http://www.w3.org/2000/01/rdf-schema#comment | "The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of beta-catenin, which then binds T cell factor-4 (Tcf-4), causing increased transcriptional activation of unknown genes. Here, the c-MYC oncogene is identified as a target gene in this signaling pathway. Expression of c-MYC was shown to be repressed by wild-type APC and activated by beta-catenin, and these effects were mediated through Tcf-4 binding sites in the c-MYC promoter. These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.281.5382.1509"xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.281.5382.1509"xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "He T.-C."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "He T.-C."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Hermeking H."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Hermeking H."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Kinzler K.W."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Kinzler K.W."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Vogelstein B."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Vogelstein B."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Morin P.J."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Morin P.J."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Rago C."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Rago C."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Sparks A.B."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Sparks A.B."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "da Costa L.T."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "da Costa L.T."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Zawel L."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/author | "Zawel L."xsd:string |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9727977 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |