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| http://purl.uniprot.org/citations/9729467 | http://www.w3.org/2000/01/rdf-schema#comment | "The docking protein p130(cas) (Crk-associated substrate) forms a stable complex with the adaptor protein CrkII in a tyrosine-phosphorylation-dependent manner. Insulin-induced tyrosine phosphorylation of insulin receptor substrates results in the redistribution of CrkII between p130(cas) and insulin receptor substrate-1. A decrease in the association between CrkII and p130(cas) in response to insulin stimulation was detected in CHO cells stably expressing insulin receptor or insulin receptor substrate-1, and in L6 rat myoblasts. Along with the decrease in the association of CrkII with p130(cas), the amount of tyrosine-phosphorylated insulin receptor substrate-1 co-precipitated with CrkII increased in all cell types studied. The insulin-induced decrease in the CrkII-p130(cas) association was further confirmed by Far Western Blot analysis with the Src homology 2 (SH2) domain of CrkII. Insulin regulates the association of CrkII with p130(cas) by tyrosine dephosphorylation of p130(cas) and co-ordinated tyrosine phosphorylation of insulin receptor substrate-1. Tyrosine-phosphorylated insulin receptor substrate-1 serves as a docking protein for multiple adaptor proteins and competes with p130(cas) for CrkII."xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3340595"xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/author | "Sorokin A."xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/author | "Reed E."xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/pages | "595-600"xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/title | "Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1."xsd:string |
| http://purl.uniprot.org/citations/9729467 | http://purl.uniprot.org/core/volume | "334"xsd:string |
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