| http://purl.uniprot.org/citations/9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9743535 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokines stimulate granulopoiesis through signaling via receptors whose expression is controlled by lineage-specific transcription factors. Previously, we demonstrated that granulocyte colony-stimulating factor (G-CSF) receptor mRNA was undetectable and granulocyte maturation blocked in CCAAT enhancer binding protein alpha (C/EBPalpha)-deficient mice. This phenotype is distinct from that of G-CSF receptor-/-mice, suggesting that other genes are likely to be adversely affected by loss of C/EBPalpha. Here we demonstrate loss of interleukin 6 (IL-6) receptor and IL-6-responsive colony-forming units (CFU-IL6) in C/EBPalpha-/-mice. The observed failure of granulopoiesis could be rescued by the addition of soluble IL-6 receptor and IL-6 or by retroviral transduction of G-CSF receptors, demonstrating that loss of both of these receptors contributes to the absolute block in granulocyte maturation observed in C/EBPalpha-deficient hematopoietic cells. The results of these and other studies suggest that additional C/EBPalpha target genes, possibly other cytokine receptors, are also important for the block in granulocyte differentiation observed in vivo in C/EBPalpha-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.188.6.1173"xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/author | "Iwama A."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/author | "Link D.C."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/author | "Darlington G.J."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/author | "Datta M.W."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/pages | "1173-1184"xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/title | "Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis."xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/9743535 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9743535 |
| http://purl.uniprot.org/citations/9743535 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9743535 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF1-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPE0-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
| http://purl.uniprot.org/uniprot/#_Q0VB73-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
| http://purl.uniprot.org/uniprot/#_P35659-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
| http://purl.uniprot.org/uniprot/#_P09920-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
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| http://purl.uniprot.org/uniprot/#_P49715-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
| http://purl.uniprot.org/uniprot/#_P53566-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |
| http://purl.uniprot.org/uniprot/#_Q3UM22-mappedCitation-9743535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9743535 |