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http://purl.uniprot.org/citations/9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/9744378http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Acute anterior uveitis is strongly associated with the HLA-B27 antigen and triggered by the involvement of some external factors. However, it is uncertain whether HLA-B27 itself or other gene(s) near the HLA-B region in a linkage disequilibrium with HLA-B27 predispose to this uveitis. We therefore investigated microsatellite polymorphism in the transmembrane region of the major histocompatibility complex class I chain-related gene A (MICA), located 47 kilobases (kb) on the centromeric side of the HLA-B gene on the short arm of chromosome 6 within 6p21.3.

Methods

We examined the following patients for MICA gene polymorphism by means of polymerase chain reaction and subsequent automated fragment detection by fluorescent-based technology: 64 (37 HLA-B27-positive and 27 HLA-B27-negative) whites with acute anterior uveitis, 74 (67 HLA-B27-negative and 7 HLA-B27-positive) ethnically matched random controls, and 36 HLA-B27-positive healthy controls.

Results

The microsatellite allele consisting of four repetitions of GCT/AGC (designated A4 allele) was present at the significantly higher phenotype frequency (71.9%) in the patient group than in the ethnically matched random control group (13.5%) (P < .0000001, corrected P < .0000001). The A4 allele was strongly linked to HLA-B27 in a white population. However, the A4 allele was also found at the significantly higher phenotype frequency (37.0%) even in the HLA-B27-negative patient group than in the ethnically matched HLA-B27-negative control group (4.5%) (P = .0086, corrected P = .043).

Conclusions

These results suggest that the MICA gene itself or other nearby gene(s) linked to the MICA A4 allele may be involved in the development of acute anterior uveitis in a white population."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.org/dc/terms/identifier"doi:10.1016/s0002-9394(98)00100-7"xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Kimura M."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Goto K."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Inoko H."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Ohno S."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Katsuyama Y."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Ota M."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Yabuki K."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Mizuki N."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/author"Maksymowych W.P."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/date"1998"xsd:gYear
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/name"Am J Ophthalmol"xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/pages"436-441"xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/title"Association between MICA gene A4 allele and acute anterior uveitis in white patients with and without HLA-B27."xsd:string
http://purl.uniprot.org/citations/9744378http://purl.uniprot.org/core/volume"126"xsd:string
http://purl.uniprot.org/citations/9744378http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/9744378
http://purl.uniprot.org/citations/9744378http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/9744378
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9744378
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9744378
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9744378
http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9744378
http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9744378
http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-9744378http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/9744378
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