| http://purl.uniprot.org/citations/9750000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9750000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9750000 | http://www.w3.org/2000/01/rdf-schema#comment | "A cDNA clone, encoding a complete porcine EP3 receptor, was isolated from a porcine heart cDNA library. The deduced amino acid sequence revealed a protein of 387 amino acid residues with an estimated molecular weight of 43 kD and strongest homology to the human EP3-II receptor (84% identity on protein level). Ligand binding studies with transfected COS-7 cells, expressing the porcine receptor, showed displacement of [3H]PGE1 with the EP3-specific agonist M&B 28.767, the EP1/EP3-agonist sulprostone but not with the EP2-specific agonist butaprost. Stimulation of transfected CHO cells with M&B 28.767 resulted in inhibition of forskolin-induced cAMP formation, suggesting coupling to an inhibitory G protein. Agonist-induced translocation of the transcription factor NFkappaB into the nucleus of transfected CHO cells was demonstrated by Western blot analysis, indicating that these EP3 receptors modulate NFkappaB-dependent cellular signal transduction. Analysis of the genomic organization identified the major transcription initiation site at about 160 bp upstream of the ATG start codon. The 800-bp 5' flanking region contains a variety of putative cis-acting regulatory elements, including binding sites for AP2, SP1 and MyoD (E-box). The present data will now allow further studies on EP3 receptor-mediated signal transduction and its regulation."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.org/dc/terms/identifier | "doi:10.1007/PL00005238"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.org/dc/terms/identifier | "doi:10.1007/pl00005238"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Kuger P."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Kuger P."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Hohlfeld T."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Hohlfeld T."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Meyer-Kirchrath J."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Meyer-Kirchrath J."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Schror K."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/author | "Schror K."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/name | "Naunyn Schmiedebergs Arch. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/name | "Naunyn Schmiedebergs Arch Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/pages | "160-167"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/pages | "160-167"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/title | "Analysis of a porcine EP3-receptor: cloning, expression and signal transduction."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/title | "Analysis of a porcine EP3-receptor: cloning, expression and signal transduction."xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/volume | "358"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://purl.uniprot.org/core/volume | "358"xsd:string |
| http://purl.uniprot.org/citations/9750000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9750000 |
| http://purl.uniprot.org/citations/9750000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9750000 |