| http://purl.uniprot.org/citations/9751710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9751710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9751710 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian AML/CBFalpha runt domain (RD) transcription factors regulate hematopoiesis and osteoblast differentiation. Like their Drosophila counterparts, most mammalian RD proteins terminate in a common pentapeptide, VWRPY, which serves to recruit the corepressor Groucho (Gro). Using a yeast two-hybrid assay, in vitro association and pull-down experiments, we demonstrate that Gro and its mammalian homolog TLE1 specifically interact with AML1 and AML2. In addition to the VWRPY motif, other C-terminal sequences are required for these interactions with Gro/TLE1. TLE1 inhibits AML1-dependent transactivation of the T cell receptor (TCR) enhancers alpha and beta, which contain functional AML binding sites, in transfected Jurkat T cells. LEF-1 is an additional transcription factor that mediates transactivation of TCR enhancers. LEF-1 and its Drosophila homolog Pangolin (Pan) are involved in the Wnt/Wg signaling pathway through interactions with the coactivator beta-catenin and its highly conserved fly homolog Armadillo (Arm). We show that TLE/Gro interacts with LEF-1 and Pan, and inhibits LEF-1:beta-catenin-dependent transcription. These data indicate that, in addition to their activity as transcriptional activators, AML1 and LEF-1 can act, through recruitment of the corepressor TLE1, as transcriptional repressors in TCR regulation and Wnt/Wg signaling."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.20.11590"xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.20.11590"xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Groner Y."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Groner Y."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Goldstein R.E."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Goldstein R.E."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Paroush Z."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Paroush Z."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Goldenberg D."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Goldenberg D."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Bernstein Y."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Bernstein Y."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Stifani S."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Stifani S."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Levanon D."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/author | "Levanon D."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/9751710 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |