| http://purl.uniprot.org/citations/9753625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9753625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9753625 | http://www.w3.org/2000/01/rdf-schema#comment | "Homeodomain proteins play important roles in animal development by controlling the expression of genes involved in determining cell fates. The recently cloned human Cart1 gene encodes a paired-class homeodomain (hCART1), whose rodent homolog is mainly expressed in early chondrocytes and in prechondrocytic mesenchymal cells. To better understand its role as a transcription factor, the author has selected specific hCART1 binding sites from a random pool of oligonucleotides. It is reported here that all sites obtained contain a palindrome consisting of two TAAT sequences separated by three or four base pairs. In electromobility shift assays, recombinant hCART1 proteins bind to a palindromic probe as a multimer, possibly a homodimer. In transient transfection assays, hCART1 activates transcription from reporter plasmids containing hCART1 binding sites in HeLa cells, demonstrating both site-dependence and dosage-dependence. It is also shown here that hCART1 localizes to nucleus. These data indicate that hCART1 is a sequence-specific transcription activator in HeLa cells. In combination with data from previous studies in which hCART1 represses transcription in different cell types and promoters, they suggest that hCART1 may be a transcription modulator with both repression and activation activities."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.9257"xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1998.9257"xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/author | "Cai R.L."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/author | "Cai R.L."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/pages | "305-311"xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/pages | "305-311"xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/title | "Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/title | "Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites."xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/volume | "250"xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://purl.uniprot.org/core/volume | "250"xsd:string |
| http://purl.uniprot.org/citations/9753625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9753625 |
| http://purl.uniprot.org/citations/9753625 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9753625 |
| http://purl.uniprot.org/citations/9753625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9753625 |
| http://purl.uniprot.org/citations/9753625 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9753625 |
| http://purl.uniprot.org/uniprot/Q15699 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9753625 |
| http://purl.uniprot.org/uniprot/Q15699#attribution-785B24E10384FADDA86DE37B2A801426 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9753625 |
| http://purl.uniprot.org/uniprot/Q15699#attribution-7D06A7766F400F70BA67C0C7371D5C07 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9753625 |
| http://purl.uniprot.org/uniprot/Q15699#attribution-EC13EFE39C0095886C31238CAC5EAD1A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9753625 |