| http://purl.uniprot.org/citations/9755127 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9755127 | http://www.w3.org/2000/01/rdf-schema#comment | "We isolated and characterized the cDNAs for the human, pig, and Caenorhabditis elegans K-Cl cotransporters. The pig and human homologs are 94% identical and contain 1,085 and 1,086 amino acids, respectively. The deduced protein of the C. elegans K-Cl cotransporter clone (CE-KCC1) contains 1,003 amino acids. The mammalian K-Cl cotransporters share approximately 45% similarity with CE-KCC1. Hydropathy analyses of the three clones indicate typical KCC topology patterns with 12 transmembrane segments, large extracellular loops between transmembrane domains 5 and 6 (unique to KCC), and large COOH-terminal domains. Human KCC1 is widely expressed among various tissues. This KCC1 gene spans 23 kb and is organized in 24 exons, whereas the CE-KCC1 gene spans 3.5 kb and contains 10 exons. Transiently and stably transfected human embryonic kidney cells (HEK-293) expressing the human, pig, and C. elegans K-Cl cotransporter fulfilled two (pig) or five (human and C. elegans) criteria for increased expression of the K-Cl cotransporter. The criteria employed were basal K-Cl cotransport; stimulation of cotransport by swelling, N-ethylmaleimide, staurosporine, and reduced cell Mg concentration; and secondary stimulation of Na-K-Cl cotransport."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.1998.275.4.f550"xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Kumar S.'"xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Holtzman E.J."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Dunham P.B."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Logue P.J."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Faaland C.A."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Ricken G."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Waldman J."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Warner F."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/author | "Erickson S.J."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/name | "Am J Physiol"xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/pages | "F550-64"xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/title | "Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans."xsd:string |
| http://purl.uniprot.org/citations/9755127 | http://purl.uniprot.org/core/volume | "275"xsd:string |
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