| http://purl.uniprot.org/citations/9756887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9756887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9756887 | http://www.w3.org/2000/01/rdf-schema#comment | "Hydrogen peroxide-inducible clone (Hic)-5 is induced during the senescent process in human fibroblasts, and the overexpression of Hic-5 induces a senescence-like phenotype. Structurally, Hic-5 and paxillin, a 68-kDa cytoskeletal protein, share homology such as the LD motifs in the N-terminal half and the LIM domains in the C-terminal half. Here we show that Hic-5 binds to focal adhesion kinase (FAK) by its N-terminal domain, and is localized to focal adhesions by its C-terminal LIM domains. However, Hic-5 is not tyrosine phosphorylated either by the coexpressed FAK in COS cells or by integrin stimulation in 293T cells. Furthermore, overexpression of Hic-5 results in a decreased tyrosine phosphorylation of paxillin. These findings suggest that putative functions of Hic-5 are the recruitment of FAK to focal adhesions and a competitive inhibition of tyrosine phosphorylation of paxillin."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.41.26516"xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.41.26516"xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Tachibana K."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Tachibana K."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Morimoto C."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Morimoto C."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Cho D."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Cho D."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Kamiguchi K."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Kamiguchi K."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Shibanuma M."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/author | "Shibanuma M."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/pages | "26516-26521"xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/pages | "26516-26521"xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/title | "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase."xsd:string |
| http://purl.uniprot.org/citations/9756887 | http://purl.uniprot.org/core/title | "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase."xsd:string |