| http://purl.uniprot.org/citations/9759896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9759896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9759896 | http://www.w3.org/2000/01/rdf-schema#comment | "Membrane cofactor protein (MCP; CD46) is a type 1 membrane glycoprotein that inhibits complement activation on host cells. It also is a measles virus (MV) receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. The amino terminus of MCP consists of four complement control protein (CCP) repeats, three of which (CCP-1, -2, and -4) possess N-glycans. Immediately following the CCP modules is an alternatively spliced region for extensive O-glycosylation (termed the STP domain). Previous studies established that the N-glycan of CCP-2 is essential for MV binding and infection and that the splicing variants of the STP domain not only affect MV binding and fusion, but also differentially protect against complement-mediated cytolysis. In this report, we dissect the role of these carbohydrates on complement regulatory function. We constructed, expressed, and characterized proteins deleting these carbohydrates. For MCP-mediated protection against cytolysis, the N-glycans of CCP-2 and -4 were necessary, the STP segment influenced but was not essential, and the N-glycan of CCP-1 was not required. In addition, the rate and magnitude of cell surface cleavage of C4b to C4c and C4d by MCP and factor I correlated with cytoprotection. These studies expand the structure-function understanding of the active sites of MCP and elucidate an important role for carbohydrates in its function, a finding consistent with their conservation in the MCP of other species."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/author | "Liszewski M.K."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/author | "Liszewski M.K."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/author | "Leung M.K."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/author | "Leung M.K."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/pages | "3711-3718"xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/pages | "3711-3718"xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/title | "Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/title | "Membrane cofactor protein: importance of N- and O-glycosylation for complement regulatory function."xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://purl.uniprot.org/core/volume | "161"xsd:string |
| http://purl.uniprot.org/citations/9759896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9759896 |
| http://purl.uniprot.org/citations/9759896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9759896 |
| http://purl.uniprot.org/citations/9759896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9759896 |
| http://purl.uniprot.org/citations/9759896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9759896 |
| http://purl.uniprot.org/uniprot/P15529 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9759896 |
| http://purl.uniprot.org/uniprot/P15529#attribution-7EE2E83F1C6D676349FC64A2F05A032D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9759896 |