| http://purl.uniprot.org/citations/9761678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9761678 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9761678 | http://www.w3.org/2000/01/rdf-schema#comment | "The last step in cysteine biosynthesis in enteric bacteria is catalyzed by the pyridoxal 5'-phosphate-dependent enzyme O-acetylserine sulfhydrylase. Here we report the crystal structure at 2.2 A resolution of the A-isozyme of O-acetylserine sulfhydrylase isolated from Salmonella typhimurium. O-acetylserine sulfhydrylase shares the same fold with tryptophan synthase-beta from Salmonella typhimurium but the sequence identity level is below 20%. There are some major structural differences: the loops providing the interface to the alpha-subunit in tryptophan synthase-beta and two surface helices of tryptophan synthase-beta are missing in O-acetylserine sulfhydrylase. The hydrophobic channel for indole transport from the alpha to the beta active site of tryptophan synthase-beta is, not unexpectedly, also absent in O-acetylserine sulfhydrylase. The dimer interface, on the other hand, is more or less conserved in the two enzymes. The active site cleft of O-acetylserine sulfhydrylase is wider and therefore more exposed to the solvent. A possible binding site for the substrate O-acetylserine is discussed."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1998.2037"xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.1998.2037"xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Hohenester E."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Hohenester E."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Jansonius J.N."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Jansonius J.N."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Burkhard P."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Burkhard P."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Cook P.F."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Cook P.F."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Schnackerz K.D."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Schnackerz K.D."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Rao G.S.J."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/author | "Rao G.S.J."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/pages | "121-133"xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/pages | "121-133"xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/title | "Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium."xsd:string |
| http://purl.uniprot.org/citations/9761678 | http://purl.uniprot.org/core/title | "Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium."xsd:string |