| http://purl.uniprot.org/citations/9762362 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9762362 | http://www.w3.org/2000/01/rdf-schema#comment | "The nucleus was shown to be a site for inositol lipid cycle which can be affected by treatment of quiescent cells with growth factors such as IGF-I. In fact, the exposure of Swiss 3T3 cells to IGF-I results in a rapid and transient increase in nuclear PLC beta 1 activity. In addition, several other reports have shown the involvement of PLC beta 1 in nuclear signalling in different cell types. Indeed, PLC beta 1 differs from the PLC gamma and della isozymes in that it has a long COOH-terminal sequence which contains a cluster of lysine residues that are critical for association with the nucleus. Although the demonstration of PtInsP and PtdInsP2 hydrolysis by nuclear PLC beta 1 established the existence of nuclear PLC signalling, the significance of this autonomous pathway in the nucleus has yet to be thoroughly clarified. By inducing both the inhibition of PLC beta 1 expression by antisense RNA and its overexpression we show that this nuclear PLC is essential for the onset of DNA synthesis following IGF-I stimulation of quiescent Swiss 3T3 cells. Moreover, using a different cell system, i.e. Friend erythroleukemia cells induced to differentiate towards erythrocytes, it has been evidenced that there is a relationship between the expression and activity of nuclear PLC beta 1 and the association of PI-PT alpha with the nucleus in that, when PLC activity ceases, in differentiated and resting cells at the same time there is a dramatic decrease of the association of PI-PT alpha with the nucleus."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0065-2571(97)00014-9"xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Rhee S.G."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Maraldi N.M."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Cocco L."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Gilmour R.S."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Barnabei O."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Manzoli F.A."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Rizzoli R."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Wirtz K.W."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Capitani S."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/author | "Mazzotti G."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/name | "Adv Enzyme Regul"xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/pages | "351-363"xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/title | "Inositides in the nucleus: taking stock of PLC beta 1."xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/9762362 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9762362 |
| http://purl.uniprot.org/citations/9762362 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9762362 |
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