| http://purl.uniprot.org/citations/9763617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9763617 | http://www.w3.org/2000/01/rdf-schema#comment | "CD3gamma and CD3delta are two highly related components of the T cell receptor (TCR)-CD3 complex which is essential for the assembly and signal transduction of the T cell receptor on mature T cells. In gene knockout mice deficient in either CD3delta or CD3gamma, early thymic development mediated by pre-TCR was either undisturbed or severely blocked, respectively, and small numbers of TCR-alphabeta+ T cells were detected in the periphery of both mice. gammadelta T cell development was either normal in CD3delta-/-mice or partially blocked in CD3gamma-/-mice. To examine the collective role of CD3gamma and CD3delta in the assembly and function of pre-TCR and in the development of gammadelta T cells, we generated a mouse strain with a disruption in both CD3gamma and CD3delta genes (CD3gammadelta-/-). In contrast to mice deficient in either CD3gamma or CD3delta chains, early thymic development mediated by pre-TCR is completely blocked, and TCR-alphabeta+ or TCR-gammadelta+ T cells were absent in the CD3gammadelta-/-mice. Taken together, these studies demonstrated that CD3gamma and CD3delta play an essential, yet partially overlapping, role in the development of both alphabeta and gammadelta T cell lineages."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.188.7.1375"xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "Sharpe A."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "She J."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "Allen D."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/author | "Salio M."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/pages | "1375-1380"xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/title | "Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://purl.uniprot.org/core/volume | "188"xsd:string |
| http://purl.uniprot.org/citations/9763617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9763617 |
| http://purl.uniprot.org/citations/9763617 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9763617 |
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| http://purl.uniprot.org/uniprot/#_Q3U572-mappedCitation-9763617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9763617 |