| http://purl.uniprot.org/citations/9766630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9766630 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipopolysaccharide-induced CXC chemokine (LIX) is a novel murine neutrophil-chemoattractant CXC chemokine cloned as a glucocorticoid-attenuated response gene. We investigated LIX message expression in an acute endotoxemia model. LIX message peaks later than KC or macrophage inflammatory protein-2 (MIP-2) and remains elevated longer in almost all tissues. Induced LIX message expression in heart is 5-to 6-fold greater than in lung and spleen, and 20-fold greater than in liver. In contrast, KC expression is equal in heart, lung, and liver, whereas MIP-2 expression is strongest in the lung. Glucocorticoid regulation of these genes also differs. Endotoxemia-induced LIX message expression in the lung is markedly enhanced in adrenalectomized mice and strongly attenuated by dexamethasone, whereas lung KC and MIP-2 expression are unaffected by glucocorticoids. It is surprising to note that endotoxemia-induced brain expression of LIX (but not KC or MIP-2) is increased by dexamethasone. These observations suggest that LIX may have biological roles distinct from KC and MIP-2."xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.org/dc/terms/identifier | "doi:10.1002/jlb.64.4.494"xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/author | "Herschman H.R."xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/author | "Smith J.B."xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/author | "Rovai L.E."xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/pages | "494-502"xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/title | "The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia."xsd:string |
| http://purl.uniprot.org/citations/9766630 | http://purl.uniprot.org/core/volume | "64"xsd:string |
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