| http://purl.uniprot.org/citations/9767597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9767597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9767597 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned and characterized a Saccharomyces cerevisiae gene YRR1 that is important for resistance to the mutagen 4-nitroquinoline N-oxide (4-NQO). The wild-type YRR1 gene encodes a protein that contains a Zn(II)2Cys6-type zinc-finger motif. Disruption of the YRR1 gene leads to hypersensitivity to 4-NQO. A dominant mutation (YRR1-1) that confers strong resistance to 4-NQO has been identified. Epistasis analysis demonstrated that 4-NQO resistances mediated by the YRR1 and YRR1-1 alleles require the presence of the SNQ2 gene that encodes a multidrug resistance ATP binding cassette superfamily protein responsible for 4-NQO export. Northern blot analysis of SNQ2 mRNA levels indicated that Yrr1p is involved in basal and drug-induced transcriptional activation of SNQ2, whereas Pdr1p/Pdr3p transcription factors are mainly involved in basal SNQ2 expression. In the YRR1-1 mutant, the level of SNQ2 mRNA is constitutively elevated. These results establish that Yrr1p is important for 4-NQO resistance by mediating transcriptional activation of the SNQ2 gene in response to the stress imposed by 4-NQO. The gain-of-function mutation of Yrr1-1p was attributable to the duplication of a 12-amino-acid sequence generated near the carboxy terminus."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2958.1998.01027.x"xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2958.1998.01027.x"xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Cui Z."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Cui Z."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Shiraki T."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Shiraki T."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Hirata D."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Hirata D."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Miyakawa T."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/author | "Miyakawa T."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/pages | "1307-1315"xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/pages | "1307-1315"xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/title | "Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/title | "Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2."xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/9767597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9767597 |
| http://purl.uniprot.org/citations/9767597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9767597 |