| http://purl.uniprot.org/citations/9770513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9770513 | http://www.w3.org/2000/01/rdf-schema#comment | "We obtained mice deficient for major histocompatibility complex (MHC) molecules encoded by the H-2K and H-2D genes. H-2 KbDb -/-mice express no detectable classical MHC class I-region associated (Ia) heavy chains, although beta2-microglobulin and the nonclassical class Ib proteins examined are expressed normally. KbDb -/-mice have greatly reduced numbers of mature CD8+ T cells, indicating that selection of the vast majority (>90%) of CD8+ T cells cannot be compensated for by beta2-microglobulin-associated molecules other than classical H-2K and D locus products. In accord with the greatly reduced number of CD8+ T cells, spleen cells from KbDb -/-mice do not generate cytotoxic responses in primary mixed-lymphocyte cultures against MHC-disparate (allogeneic) cells. However, in vivo priming of KbDb -/-mice with allogeneic cells resulted in strong CD8+ MHC class Ia-specific allogeneic responses. Thus, a minor population of functionally competent peripheral CD8+ T cells capable of strong cytotoxic activity arises in the complete absence of classical MHC class Ia molecules. KbDb -/-animals also have natural killer cells that retain their cytotoxic potential."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.95.21.12492"xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/author | "Eisen H."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/author | "Ploegh H."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/author | "Glas R."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/author | "Perarnau B."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/author | "Vugmeyster Y."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/pages | "12492-12497"xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/title | "Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells."xsd:string |
| http://purl.uniprot.org/citations/9770513 | http://purl.uniprot.org/core/volume | "95"xsd:string |
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