| http://purl.uniprot.org/citations/9778254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9778254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9778254 | http://www.w3.org/2000/01/rdf-schema#comment | "Flap endonuclease (FEN-1) removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. The crystal structure of Pyrococcus furiosus FEN-1, active-site metal ions, and mutational information indicate interactions for the single- and double-stranded portions of the flap DNA substrate and identify an unusual DNA-binding motif. The enzyme's active-site structure suggests that DNA binding induces FEN-1 to clamp onto the cleavage junction to form the productive complex. The conserved FEN-1 C terminus binds proliferating cell nuclear antigen (PCNA) and positions FEN-1 to act primarily as an exonuclease in DNA replication, in contrast to its endonuclease activity in DNA repair. FEN-1 mutations altering PCNA binding should reduce activity during replication, likely causing DNA repeat expansions as seen in some cancers and genetic diseases."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81789-4"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81789-4"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Shen B."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Tainer J.A."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Tainer J.A."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Hosfield D.J."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Hosfield D.J."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Mol C.D."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/author | "Mol C.D."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/pages | "135-146"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/pages | "135-146"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/title | "Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/title | "Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity."xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/9778254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9778254 |
| http://purl.uniprot.org/citations/9778254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9778254 |