| http://purl.uniprot.org/citations/9788969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9788969 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the low density lipoprotein receptor (LDLR) in the clearance of apo-B48-containing lipoproteins and the role of the LDLR-related protein (LRP) in the removal of apo-B100-containing lipoproteins have not been clearly defined. To address these issues, we characterized LDLR-deficient mice homozygous for an "apo-B48-only" allele, an "apo-B100-only" allele, or a wild-type apo-B allele (Ldlr-/-Apob48/48, Ldlr-/-Apob100/100, and Ldlr-/-Apob+/+, respectively). The plasma apo-B48 and LDL cholesterol levels were higher in Ldlr-/-Apob48/48 mice than in Apob48/48 mice, indicating that the LDL receptor plays a significant role in the removal of apo-B48-containing lipoproteins. To examine the role of the LRP in the clearance of apo-B100-containing lipoproteins, we blocked hepatic LRP function in Ldlr-/-Apob100/100 mice by adenoviral-mediated expression of the receptor-associated protein (RAP). RAP expression did not change apo-B100 levels in Ldlr-/-Apob100/100 mice. In contrast, RAP expression caused a striking increase in plasma apo-B48 levels in Apob48/48 and Ldlr-/-Apob48/48 mice. These data imply that LRP is important for the clearance of apo-B48-containing lipoproteins but plays no significant role in the clearance of apo-B100-containing lipoproteins."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci4164"xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Herz J."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Young S.G."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Pierotti V."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Walzem R.L."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Driscoll R."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Veniant M.M."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Zlot C.H."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/author | "Dichek D."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/pages | "1559-1568"xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/title | "Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice."xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/9788969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9788969 |
| http://purl.uniprot.org/citations/9788969 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9788969 |
| http://purl.uniprot.org/uniprot/P08226#attribution-A49F343C4A0E9A8273CB362C7E7E0132 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9788969 |
| http://purl.uniprot.org/uniprot/P35951#attribution-A49F343C4A0E9A8273CB362C7E7E0132 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9788969 |
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| http://purl.uniprot.org/uniprot/#_E9Q1Y3-mappedCitation-9788969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/9788969 |