| http://purl.uniprot.org/citations/9792637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9792637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9792637 | http://www.w3.org/2000/01/rdf-schema#comment | "Overexpression of a catalytically inactive mutant of tyrosine phosphatase SHP-2 in 293 cells resulted in hyperphosphorylation of a glycoprotein specifically associated with the enzyme. The protein has been purified to near homogeneity. Based on the amino acid sequences of peptides obtained from the protein, a full-length cDNA was isolated. The cDNA encodes a protein with a single transmembrane segment and a signal sequence. The extracellular portion of the protein contains a single immunoglobulin-like domain displaying 46% sequence identity to that of myelin P0, a major structural protein of peripheral myelin. The intracellular segment of the protein shows no significant sequence identity to any known protein except for two immunoreceptor tyrosine-based inhibitory motifs. We name the protein PZR for protein zero related. Transfection of the PZR cDNA in Jurkat cells gave rise to a protein of expected molecular size. Stimulation of cells with pervanadate resulted in tyrosine phosphorylation of PZR and a near-stoichiometric association of PZR with SHP-2. Northern blotting analyses revealed that PZR is widely expressed in human tissues and is particularly abundant in heart, placenta, kidney, and pancreas. As a binding protein and a putative substrate of SHP-2, PZR protein may have an important role in cell signaling."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.45.29367"xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.273.45.29367"xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/author | "Zhao R."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/author | "Zhao R."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/author | "Zhao Z.J."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/author | "Zhao Z.J."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/pages | "29367-29372"xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/pages | "29367-29372"xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/title | "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/title | "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2."xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://purl.uniprot.org/core/volume | "273"xsd:string |
| http://purl.uniprot.org/citations/9792637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9792637 |
| http://purl.uniprot.org/citations/9792637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/9792637 |
| http://purl.uniprot.org/citations/9792637 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9792637 |
| http://purl.uniprot.org/citations/9792637 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/9792637 |
| http://purl.uniprot.org/uniprot/O95297 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/9792637 |
| http://purl.uniprot.org/uniprot/O95297#attribution-33991A8FB680237A6C218038A8F2865F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/9792637 |