| http://purl.uniprot.org/citations/9806545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9806545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9806545 | http://www.w3.org/2000/01/rdf-schema#comment | "The PML gene of acute promyelocytic leukaemia (APL) encodes a cell growth and tumour suppressor, however, the mechanisms by which PML suppresses tumorigenesis are poorly understood. We show here that Pml is required for Fas- and caspase-dependent DNA-damage-induced apoptosis. We also found that Pml is essential for induction of programmed cell death by Fas, tumour necrosis factor alpha (TNF), ceramide and type I and II interferons (IFNs). As a result, Pml-/-mice and cells are protected from the lethal effects of ionizing radiation and anti-Fas antibody. Pml is required for caspase 1 and caspase 3 activation upon exposure to these stimuli. The PML-RAR alpha fusion protein of APL renders haemopoietic progenitor cells resistant to Fas-, TNF- and IFN-induced apoptosis with a lack of caspase 3 activation, thus acting as a Pml dominant-negative product. These results demonstrate that Pml is a mediator of multiple apoptotic signals, and implicate inhibition of apoptosis in the pathogenesis of APL."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.org/dc/terms/identifier | "doi:10.1038/3073"xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.org/dc/terms/identifier | "doi:10.1038/3073"xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Ruggero D."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Ruggero D."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Zhong S."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Zhong S."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Wang Z.G."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Wang Z.G."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Rivi R."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Rivi R."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Ronchetti S."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Ronchetti S."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Gaboli M."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/author | "Gaboli M."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/pages | "266-272"xsd:string |
| http://purl.uniprot.org/citations/9806545 | http://purl.uniprot.org/core/pages | "266-272"xsd:string |