| http://purl.uniprot.org/citations/9813088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/9813088 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of lines of evidence point to a predominance of cytokinesis defects in spermatogenesis in hypomorphic alleles of the Drosophila polo gene. In the pre-meiotic mitoses, cytokinesis defects result in cysts of primary spermatocytes with reduced numbers of cells that can contain multiple centrosomes. These are connected by a correspondingly reduced number of ring canals, structures formed by the stabilization of the cleavage furrow. The earliest defects during the meiotic divisions are a failure to form the correct mid-zone and mid-body structures at telophase. This is accompanied by a failure to correctly localize the Pavarotti kinesin-like protein that functions in cytokinesis, and of the septin Peanut and of actin to be incorporated into a contractile ring. In spite of these defects, cyclin B is degraded and the cells exit M phase. The resulting spermatids are frequently binuclear or tetranuclear, in which case they develop either two or four axonemes, respectively. A significant proportion of spermatids in which cytokinesis has failed may also show the segregation defects previously ascribed to polo1 mutants. We discuss these findings in respect to conserved functions for the Polo-like kinases in regulating progression through M phase, including the earliest events of cytokinesis."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.143.3.659"xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Glover D.M."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Adams R."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Callaini G."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Riparbelli M.G."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Carmena M."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Minestrini G."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/author | "Tavares A.M."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/date | "1998"xsd:gYear |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/pages | "659-671"xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/title | "Drosophila polo kinase is required for cytokinesis."xsd:string |
| http://purl.uniprot.org/citations/9813088 | http://purl.uniprot.org/core/volume | "143"xsd:string |
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